Ángel Santos Montes

Researcher and professor

Full Professor, Dept. of Biochemistry, Faculty of Medicine, Complutense University of Madrid, Spain.


Pharmacology, Genetics and Behavior


1: Cortes-Canteli M, Aguilar-Morante D, Sanz-Sancristobal M, Megias D, Santos A, Perez-Castillo A. Role of C/EBPβ transcription factor in adult hippocampal neurogenesis. PLoS One. 2011;6(10):e24842. Epub 2011 Oct 7. PubMed PMID: 22003384; PubMed Central PMCID: PMC3189174.

2: Morales-Garcia JA, Redondo M, Alonso-Gil S, Gil C, Perez C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease. PLoS One. 2011 Feb 24;6(2):e17240. PubMed PMID: 21390306; PubMed Central PMCID: PMC3044733.

3: Aguilar-Morante D, Cortes-Canteli M, Sanz-Sancristobal M, Santos A, Perez Castillo A. Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells. Neuroscience. 2011 Mar 10;176:110-9. Epub 2010 Dec 23. PubMed PMID: 21185356.

4: Morales-Garcia JA, Luna-Medina R, Alfaro-Cervello C, Cortes-Canteli M, Santos A, Garcia-Verdugo JM, Perez-Castillo A. Peroxisome proliferator activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo. Glia. 2011 Feb;59(2):293-307. PubMed PMID: 21125653.

5: Aguilar-Morante D, Morales-Garcia JA, Sanz-SanCristobal M, Garcia Cabezas MA, Santos A, Perez-Castillo A. Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8. PLoS One. 2010 Nov 8;5(11):e13879. PubMed PMID: 21079728; PubMed Central PMCID: PMC2975629.

6: Giné E, Morales-Garcia JA, Perez-Castillo A, Santos A. Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat. Endocrinology. 2010 Jul;151(7):3267-76. Epub 2010 Apr 21. PubMed PMID: 20410204.

7: Cocca C, Dorado J, Calvo E, López JA, Santos A, Perez-Castillo A. 15 Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. Biochem Pharmacol. 2009 Nov 15;78(10):1330-9. Epub 2009 Jul 1. PubMed PMID: 19576185.

8: Alén F, Santos A, Moreno-Sanz G, González-Cuevas G, Giné E, Franco-Ruiz L, Navarro M, López-Moreno JA. Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D aspartate receptors. Neuroscience. 2009 Jan 23;158(2):465-73. Epub 2008 Oct 10. PubMed PMID: 18977415.

9: Morales-Garcia JA, Luna-Medina R, Martinez A, Santos A, Perez-Castillo A. Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats. J Neurosci Res. 2009 Dec;87(16):3687-96. PubMed PMID: 19565651.

10: Martinez B, Rodrigues TB, Gine E, Kaninda JP, Perez-Castillo A, Santos A. Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats. Endocrinology. 2009 Aug;150(8):3953-9. Epub 2009 Apr 23. PubMed PMID: 19389834.

11: Cortes-Canteli M, Luna-Medina R, Sanz-Sancristobal M, Alvarez-Barrientos A, Santos A, Perez-Castillo A. CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury. J Cell Sci. 2008 Apr 15;121(Pt 8):1224-34. PubMed PMID: 18388310.

12: Asúa T, Bilbao A, Gorriti MA, Lopez-Moreno JA, Del Mar Alvarez M, Navarro M, Rodríguez de Fonseca F, Perez-Castillo A, Santos A. Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism. Endocrinology. 2008 May;149(5):2657-66. Epub 2008 Jan 24. PubMed PMID: 18218697.

13: Luna-Medina R, Cortes-Canteli M, Sanchez-Galiano S, Morales-Garcia JA, Martinez A, Santos A, Perez-Castillo A. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci. 2007 May 23;27(21):5766-76. PubMed PMID: 17522320.

14: Sanchez-Rodriguez J, Kaninda-Tshilumbu JP, Santos A, Perez-Castillo A. The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. Biochem J. 2005 Aug 15;390(Pt 1):57-65. PubMed PMID: 15819613; PubMed Central PMCID: PMC1188266.

15: Luna-Medina R, Cortes-Canteli M, Alonso M, Santos A, Martínez A, Perez Castillo A. Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. J Biol Chem. 2005 Jun 3;280(22):21453-62. Epub 2005 Apr 6. PubMed PMID: 15817469.

16: Alvarez M, Perez-Castillo A, Santos A. Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development. J Neurochem. 2005 Jan;92(2):395-404. PubMed PMID: 15663487.

17: Martínez B, Pérez-Castillo A, Santos A. The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. J Lipid Res. 2005 Apr;46(4):736-43. Epub 2005 Jan 16. PubMed PMID: 15654126.

18: Pignatelli M, Sánchez-Rodríguez J, Santos A, Perez-Castillo A. 15-deoxy Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism. Carcinogenesis. 2005 Jan;26(1):81-92. Epub 2004 Oct 14. PubMed PMID: 15485993.

19: Pignatelli M, Cocca C, Santos A, Perez-Castillo A. Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line. Oncogene. 2003 Aug 21;22(35):5446-50. PubMed PMID: 12934104.

20: Pignatelli M, Luna-Medina R, Pérez-Rendón A, Santos A, Perez-Castillo A. The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells. Biochem J. 2003 Aug 1;373(Pt 3):739-46. PubMed PMID: 12755686; PubMed Central PMCID: PMC1223559.

21: Cortés-Canteli M, Pignatelli M, Santos A, Perez-Castillo A. CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells. J Biol Chem. 2002 Feb 15;277(7):5460-7. Epub 2001 Dec 3. PubMed PMID: 11733516.

22: Pignatelli M, Cortés-Canteli M, Lai C, Santos A, Perez-Castillo A. The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. J Cell Sci. 2001 Nov;114(Pt 22):4117-26. PubMed PMID: 11739643.

23: Martinez B, del Hoyo P, Martin MA, Arenas J, Perez-Castillo A, Santos A. Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. J Neurochem. 2001 Sep;78(5):1054-63. PubMed PMID: 11553679.

24: Menéndez-Hurtado A, Santos A, Pérez-Castillo A. Characterization of the promoter region of the rat CCAAT/enhancer-binding protein alpha gene and regulation by thyroid hormone in rat immortalized brown adipocytes. Endocrinology. 2000 Nov;141(11):4164-70. PubMed PMID: 11089549.

25: Pignatelli M, Cortés-Canteli M, Santos A, Perez-Castillo A. Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells. FEBS Lett. 1999 Nov 12;461(1-2):37-42. PubMed PMID: 10561492.

26: Rodríguez-Manzaneque JC, Pérez-Castillo A, Santos A. Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity. Mol Cell Endocrinol. 1998 Jun 25;141(1-2):101-10. PubMed PMID: 9723891.

27: Vega-Núñez E, Alvarez AM, Menéndez-Hurtado A, Santos A, Perez-Castillo A. Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development. Endocrinology. 1997 Sep;138(9):3771-8. PubMed PMID: 9275064.

28: Menéndez-Hurtado A, Vega-Núñez E, Santos A, Perez-Castillo A. Regulation by thyroid hormone and retinoic acid of the CCAAT/enhancer binding protein alpha and beta genes during liver development. Biochem Biophys Res Commun. 1997 May 29;234(3):605-10. PubMed PMID: 9175760.

29: Moreno B, Rodríguez-Manzaneque JC, Pérez-Castillo A, Santos A. Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats. Endocrinology. 1997 Mar;138(3):1194-203. PubMed PMID: 9048627.

30: Rodríguez-García M, Jolín T, Santos A, Pérez-Castillo A. Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes. Endocrinology. 1995 Oct;136(10):4339-50. PubMed PMID: 7664653.

31: Vega-Núñez E, Menéndez-Hurtado A, Garesse R, Santos A, Perez-Castillo A. Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning. J Clin Invest. 1995 Aug;96(2):893-9. PubMed PMID: 7635984; PubMed Central PMCID: PMC185276.

32: Mellström B, Pipaón C, Naranjo JR, Perez-Castillo A, Santos A. Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain. Endocrinology. 1994 Aug;135(2):583-8. PubMed PMID: 8033806.

33: Castelló A, Rodríguez-Manzaneque JC, Camps M, Pérez-Castillo A, Testar X, Palacín M, Santos A, Zorzano A. Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone. J Biol Chem. 1994 Feb 25;269(8):5905 12. PubMed PMID: 8119934.

34: Perez-Castillo A, Hernandez A, Pipaon C, Santos A, Obregon MJ. Multiple regulation of S14 gene expression during brown fat differentiation. Endocrinology. 1993 Aug;133(2):545-52. PubMed PMID: 8393767.

35: Pipaon C, Santos A, Perez-Castillo A. Thyroid hormone up-regulates NGFI-A gene expression in rat brain during development. J Biol Chem. 1992 Jan 5;267(1):21-3. PubMed PMID: 1370444.

36: Santos A, Perez-Castillo A, Wong NC, Oppenheimer JH. Labile proteins are necessary for T3 induction of growth hormone mRNA in normal rat pituitary and rat pituitary tumor cells. J Biol Chem. 1987 Dec 15;262(35):16880-4. PubMed PMID: 3680275.