Elena Giné Domínguez

elena.gine@med.ucm.es
Researcher and professor
PRESENT POSITION

Professor, Dept. of Cellular Biology, Faculty of Medicine, Complutense University of Madrid, Spain.

LINES OF RESEARCH

Pharmacology, Behavior and Genetics

PUBLICATIONS

17: López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P, Bernardo E, Laso FJ, Rodríguez de Fonseca F, Nadal R, Viveros MP, Maldonado R, Giné E. Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans. Alcohol Clin Exp Res. 2015 Oct;39(10):1939-50. doi: 10.1111/acer.12850.

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16. Bühler KM, Giné E, Echeverry-Alzate V, Calleja-Conde J, de Fonseca FR, López-Moreno JA. Common single nucleotide variants underlying drug addiction: more than a decade of research. Addict Biol. 2015 Jan 21. doi: 10.1111/adb.12204. [Epub ahead of print] PMID: 25603899

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15. Giné E, Echeverry-Alzate V, López-Moreno JA, López-Jimenez A, Torres-Romero D, Perez-Castillo A, Santos A. Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning. Mol Cell Endocrinol. 2013 Jan 5;365(1):119-28. doi: 10.1016/j.mce.2012.10.004. Epub 2012 Oct 16. PMID: 23079472.

14. López-Jiménez A, Walter NA, Giné E, Santos A, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. A spontaneous deletion of α-Synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption. Synapse. 2013 Jan 24. doi: 10.1002/syn.21639. [Epub ahead of print] PMID: 23345080

13. Garrido P, De Blas M, Ronzoni G, Cordero I, Antón M, Giné E, Santos A, Del Arco A, Segovia G, Mora F. Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories. J Neural Transm. 2012 Dec 20. [Epub ahead of print] PMID: 23254925

12. Echeverry-Alzate V, Tuda-Arízcun M, Bühler KM, Santos Á, Giné E, Olmos P, Gorriti MÁ, Huertas E, Rodríguez de Fonseca F, López-Moreno JA. Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: the effects on immediate-early gene expression in the rat prefrontal cortex. Neuropharmacology. 2012 Nov;63(6):927-35. doi: 10.1016/j.neuropharm.2012.06.010. Epub 2012 Jun 28. PMID: 22749946

11. García C, Gine E, Aller MA, Revuelta E, Arias JL, Vara E, Arias J. Multiple organ inflammatory response to portosystemic shunt in the rat. Cytokine. 2011 Dec;56(3):680-7. Epub 2011 Oct 4. PubMed PMID: 21975127.

10. Garrido P, De Blas M, Giné E, Santos Á, Mora F. Aging impairs the control of prefrontal cortex on the release of corticosterone in response to stress and on memory consolidation. Neurobiol Aging. 2012 Apr;33(4):827.e1-9. Epub 2011 Jul 27. PubMed PMID: 21794953.

9. Giné E, Morales-Garcia JA, Perez-Castillo A, Santos A. Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat. Endocrinology. 2010 Jul;151(7):3267-76. Epub 2010 Apr 21. PubMed PMID: 20410204.

8. Del Castillo JM, García-Martín MC, Arias-Díaz J, Giné E, Vara E, Cantero JL. Antiapoptotic effect of tacrolimus on cytokine-challenged human islets. Cell Transplant. 2009;18(10):1237-46. Epub 2009 Aug 5. PubMed PMID: 19660176.

7. Alén F, Santos A, Moreno-Sanz G, González-Cuevas G, Giné E, Franco-Ruiz L, Navarro M, López-Moreno JA. Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D aspartate receptors. Neuroscience. 2009 Jan 23;158(2):465-73. Epub 2008 Oct 10. PubMed PMID: 18977415.

6. Tamarit-Rodriguez J, Idahl LA, Giné E, Alcazar O, Sehlin J. Lactate production in pancreatic islets. Diabetes. 1998 Aug;47(8):1219-23. PubMed PMID: 9703320.

5. Bustamante J, Lobo MV, Alonso FJ, Mukala NT, Giné E, Solís JM, Tamarit Rodriguez J, Martín Del Río R. An osmotic-sensitive taurine pool is localized in rat pancreatic islet cells containing glucagon and somatostatin. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1275-85. PubMed PMID: 11701444.

4. Bustamante J, Alonso FJ, Lobo MV, Giné E, Tamarit-Rodriguez J, Solís JM, Martín del Río R. Taurine levels and localization in pancreatic islets. Adv Exp Med Biol. 1998;442:65-9. PubMed PMID: 9635015.

3. Alcázar O, Qiu-yue Z, Giné E, Tamarit-Rodriguez J. Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. Diabetes. 1997 Jul;46(7):1153-8. PubMed PMID: 9200650.

2. Alcázar O, Giné E, Qiu-Yue Z, Tamarit-Rodríguez J. The stimulation of insulin secretion by D-glyceraldehyde correlates with its rate of oxidation in islet cells. Biochem J. 1995 Aug 15;310 ( Pt 1):215-20. PubMed PMID: 7646447; PubMed Central PMCID: PMC1135875.

1. Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB, et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem. 1994 Feb 18;269(7):4895-902. PubMed PMID: 8106462.