José Antonio López Moreno

jalopezm@psi.ucm.es
Team Leader
PRESENT POSITION

Professor, Dept. of Psychobiology, Faculty of Psychology, Complutense University of Madrid, Spain.

LINES OF RESEARCH

Pharmacology, Behavior, Genetics and Prevention.

PUBLICATIONS

(In PubMed, as Lopez-Moreno JA)

29: López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P, Bernardo E, Laso FJ, Rodríguez de Fonseca F, Nadal R, Viveros MP, Maldonado R, Giné E. Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans. Alcohol Clin Exp Res. 2015 Oct;39(10):1939-50. doi: 10.1111/acer.12850.

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28: Peñasco S, Mela V, López-Moreno JA, Viveros MP, Marco EM. Early maternal Deprivation enhances voluntary alcohol inatake induced by exposure to stressful events later in life. Neural Plasticity. 2015 Jan 29

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27: Bühler KM, Giné E, Echeverry-Alzate V, Calleja-Conde J, de Fonseca FR, López-Moreno JA. Common single nucleotide variants underlying drug addiction: more than a decade of research. Addict Biol. 2015 Jan 21. doi: 10.1111/adb.12204. [Epub ahead of print] PMID: 25603899

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26: Marco EM, Echeverry-Alzate V, López-Moreno JA, Giné E, Peñasco S, Viveros MP. Consequences of early life stress on the expression of endocannabinoid-related genes in the rat brain. Behav Pharmacol. 2014 Sep;25(5-6):547-56. doi: 10.1097/FBP.0000000000000068. PubMed PMID: 25083571.

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25: Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N. Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug Des Devel Ther. 2014 Feb 20;8:263-77. doi: 10.2147/DDDT.S55045. eCollection 2014. PubMed PMID: 24591816; PubMed Central PMCID: PMC3934591.

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24: Echeverry-Alzate V, Giné E, Bühler KM, Calleja-Conde J, Olmos P, Gorriti MA, Nadal R, Rodríguez de Fonseca F, López-Moreno JA. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Br J Pharmacol. 2014 Jun;171(12):3023-36. doi: 10.1111/bph.12636. PubMed PMID: 24527678; PubMed Central PMCID: PMC4055203.

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23: Bühler KM, Huertas E, Echeverry-Alzate V, Giné E, Moltó E, Montoliu L, López-Moreno JA. Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures. Mol Genet Genomics. 2014 Jun;289(3):279-89. doi: 10.1007/s00438-013-0809-x. Epub 2014 Jan 10. PubMed PMID: 24407958.

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22: López-Jiménez A, Walter NA, Giné E, Santos A, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. A spontaneous deletion of α-Synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption. Synapse. 2013 Jan 24. doi: 10.1002/syn.21639. [Epub ahead of print] PubMed PMID: 23345080.

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21: Giné E, Echeverry-Alzate V, López-Moreno JA, López-Jimenez A, Torres-Romero D, Perez-Castillo A, Santos A. Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning. Mol Cell Endocrinol. 2013 Jan 5;365(1):119-28. doi: 10.1016/j.mce.2012.10.004. Epub 2012 Oct 16. PubMed PMID: 23079472.

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20: Echeverry-Alzate V, Tuda-Arízcun M, Bühler KM, Santos Á, Giné E, Olmos P, Gorriti MÁ, Huertas E, Rodríguez de Fonseca F, López-Moreno JA. Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: the effects on immediate-early gene expression in the rat prefrontal cortex. Neuropharmacology. 2012 Nov;63(6):927-35. doi: 10.1016/j.neuropharm.2012.06.010. Epub 2012 Jun 28. PubMed PMID: 22749946.

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19: Huertas E, Bühler KM, Echeverry-Alzate V, Giménez T, López-Moreno JA. C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate. Genes Brain Behav. 2012 Aug;11(6):677-83. doi: 10.1111/j.1601-183X.2012.00793.x. Epub 2012 May 3. PubMed PMID: 22487365.

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18: López-Moreno JA, Echeverry-Alzate V, Bühler KM. The genetic basis of the endocannabinoid system and drug addiction in humans. J Psychopharmacol. 2012 Jan;26(1):133-43. doi: 10.1177/0269881111416689. Epub 2011 Sep 21. Review. PubMed PMID: 21937688.

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17: Orio L, Crespo I, López-Moreno JA, Reyes-Cabello C, Rodríguez de Fonseca F, Gómez de Heras R. Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition. Pharmacol Biochem Behav. 2011 Apr;98(2):220-6. doi: 10.1016/j.pbb.2010.12.007. Epub 2010 Dec 14. PubMed PMID: 21163296.

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16: Zurita E, Chagoyen M, Cantero M, Alonso R, González-Neira A, López-Jiménez A, López-Moreno JA, Landel CP, Benítez J, Pazos F, Montoliu L. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res. 2011 Jun;20(3):481-9. doi: 10.1007/s11248-010-9403-8. Epub 2010 May 27. PubMed PMID: 20506040.

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15: López-Moreno JA, López-Jiménez A, Gorriti MA, de Fonseca FR. Functional interactions between endogenous cannabinoid and opioid systems: focus on alcohol, genetics and drug-addicted behaviors. Curr Drug Targets. 2010 Apr;11(4):406-28. Review. PubMed PMID: 20196742.

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14: Alén F, Mouret A, Viveros MP, Llorente R, Lepousez G, Lledo PM, López-Moreno JA. Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. Int J Neuropsychopharmacol. 2010 Mar;13(2):191-205. doi: 10.1017/S1461145709991118. Epub 2010 Jan 5. PubMed PMID: 20047713.

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13: Peraile I, Torres E, Mayado A, Izco M, Lopez-Jimenez A, Lopez-Moreno JA, Colado MI, O'Shea E. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. Br J Pharmacol. 2010 Jan;159(1):201-11. doi: 10.1111/j.1476-5381.2009.00522.x. Epub 2009 Dec 10. PubMed PMID: 20015297; PubMed Central PMCID: PMC2823365.

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12: Alén F, Gómez R, González-Cuevas G, Navarro M, López-Moreno JA. Nicotine causes opposite effects on alcohol intake: Evidence in an animal experimental model of abstinence and relapse from alcohol. Nicotine Tob Res. 2009 Nov;11(11):1304-11. doi: 10.1093/ntr/ntp139. Epub 2009 Sep 30. PubMed PMID: 19793787.

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11: Moreno-Sanz G, O'Shea E, Orio L, Escobedo I, González-Cuevas G, Navarro M, Colado MI, López-Moreno JA. Administration of MDMA to ethanol-deprived rats increases ethanol operant self-administration and dopamine release during reinstatement. Int J Neuropsychopharmacol. 2009 Aug;12(7):929-40. doi: 10.1017/S1461145709009912. Epub 2009 Feb 23. PubMed PMID: 19236733.

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10: Alén F, Santos A, Moreno-Sanz G, González-Cuevas G, Giné E, Franco-Ruiz L, Navarro M, López-Moreno JA. Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D-aspartate receptors. Neuroscience. 2009 Jan 23;158(2):465-73. doi: 10.1016/j.neuroscience.2008.10.002. Epub 2008 Oct 10. PubMed PMID: 18977415.

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9: Alen F, Moreno-Sanz G, Isabel de Tena A, Brooks RD, López-Jimenez A, Navarro M, López-Moreno JA. Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse. Eur J Neurosci. 2008 Jun;27(12):3292-8. doi: 10.1111/j.1460-9568.2008.06302.x. Epub 2008 Jun 1. PubMed PMID: 18554293.

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8: López-Moreno JA, González-Cuevas G, Moreno G, Navarro M. The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction. Addict Biol. 2008 Jun;13(2):160-87. doi: 10.1111/j.1369-1600.2008.00105.x. Epub 2008 Apr 16. Review. PubMed PMID: 18422831.

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7: López-Moreno JA, Scherma M, Rodríguez de Fonseca F, González-Cuevas G, Fratta W, Navarro M. Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2. Neurosci Lett. 2008 Mar 5;433(1):1-5. doi: 10.1016/j.neulet.2007.11.074. Epub 2007 Dec 23. PubMed PMID: 18261849.

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6: González-Cuevas G, Aujla H, Martin-Fardon R, López-Moreno JA, Navarro M, Weiss F. Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior. Neuropsychopharmacology. 2007 Nov;32(11):2260-6. Epub 2007 Mar 28. PubMed PMID: 17392740.

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5: Asúa T, Bilbao A, Gorriti MA, Lopez-Moreno JA, Del Mar Alvarez M, Navarro M, Rodríguez de Fonseca F, Perez-Castillo A, Santos A. Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism. Endocrinology. 2008 May;149(5):2657-66. doi: 10.1210/en.2007-1586. Epub 2008 Jan 24. PubMed PMID: 18218697.

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4: López-Moreno JA, González-Cuevas G, Navarro M. The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol. Neurobiol Dis. 2007 Feb;25(2):274-83. Epub 2006 Oct 24. PubMed PMID: 17067804.

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3: Moreno M, Lopez-Moreno JA, Rodríguez de Fonseca F, Navarro M. Behavioural effects of quinpirole following withdrawal of chronic treatment with the CB1 agonist, HU-210, in rats. Behav Pharmacol. 2005 Sep;16(5-6):441-6. PubMed PMID: 16148449.

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2: López-Moreno JA, Trigo-Díaz JM, Rodríguez de Fonseca F, González Cuevas G, Gómez de Heras R, Crespo Galán I, Navarro M. Nicotine in alcohol deprivation increases alcohol operant self-administration during reinstatement. Neuropharmacology. 2004 Dec;47(7):1036-44. PubMed PMID: 15555637.

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1: López-Moreno JA, González-Cuevas G, Rodríguez de Fonseca F, Navarro M. Long-lasting increase of alcohol relapse by the cannabinoid receptor agonist WIN 55,212-2 during alcohol deprivation. J Neurosci. 2004 Sep 22;24(38):8245-52. PubMed PMID: 15385608.

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